4527-4530
| Potent and Selective Thrombin Inhibitors Incorporating the Constrained Arginine Mimic L-3-Piperidyl(N-guanidino)alanine at P1
Odile E. Levy,
J. Edward Semple,
Michael L. Lim,
John Reiner,
William E. Rote,
Erin Dempsey,
Brigitte M. Richard,
Erli Zhang,
Al Tulinsky,
William C. Ripka, and
Ruth F. Nutt
[Full Article -
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4531-4536
| Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties
J. Edward Semple,
David C. Rowley,
Terence K. Brunck,
Theresa Ha-Uong,
Nathaniel K. Minami,
Timothy D. Owens,
Susan Y. Tamura,
Erick A. Goldman,
Daniel V. Siev,
Robert J. Ardecky,
Stephen H. Carpenter,
Yu Ge,
Brigitte M. Richard,
Thomas G. Nolan,
Kjell Håkanson,
Al Tulinsky,
Ruth F. Nutt, and
William C. Ripka
[Full Article -
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4537-4539
| Synthesis of Novel trans-4-(Substituted-benzamido)-3,4-dihydro-2H-benzo[b]pyran-3-ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile
Wai N. Chan,
John M. Evans,
Michael S. Hadley,
Hugh J. Herdon,
Jeffrey C. Jerman,
Helen K. A. Morgan,
Tania O. Stean,
Mervyn Thompson,
Neil Upton, and
Antonio K. Vong
[Full Article -
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4540-4546
| High-Resolution Crystal Structures of Human Cyclin-Dependent Kinase 2 with and without ATP: Bound Waters and Natural Ligand as Guides for Inhibitor Design
Ursula Schulze-Gahmen,
Hendrik L. De Bondt, and
Sung-Hou Kim
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4547-4553
| Studies on Selectin Blocker. 3. Investigation of the Carbohydrate Ligand Sialyl Lewis X Recognition Site of P-Selectin
Yasuyuki Hiramatsu,
Hideki Tsujishita, and
Hirosato Kondo
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4554-4562
| Targeting the Minor Groove of DNA: Crystal Structures of Two Complexes between Furan Derivatives of Berenil and the DNA Dodecamer d(CGCGAATTCGCG)2
John O. Trent,
George R. Clark,
Arvind Kumar,
W. David Wilson,
David W. Boykin,
James Edwin Hall,
Richard R. Tidwell,
Byron L. Blagburn, and
Stephen Neidle
[Full Article -
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4563-4568
| 2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase1a,b
Aleem Gangjee,
Farahnaz Mavandadi,
Roy L. Kisliuk,
John J. McGuire, and
Sherry F. Queener
[Full Article -
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4569-4575
| Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2'-deoxyuridine and 1- -Arabinofuranosylcytosine: Evidence of Phosphoramidase Activity
Timothy W. Abraham,
Thomas I. Kalman,
Edward J. McIntee, and
Carston R. Wagner
[Full Article -
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4576-4582
| Synthesis, Biological Evaluation, Calcium Channel Antagonist Activity, and Anticonvulsant Activity of Felodipine Coupled to a Dihydropyridine-Pyridinium Salt Redox Chemical Delivery System
Sai-hay Yiu and
Edward E. Knaus
[Full Article -
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4583-4591
| Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs
John H. Hutchinson,
Jacquelynn J. Cook,
Karen M. Brashear,
Michael J. Breslin,
Joan D. Glass,
Robert J. Gould,
Wasyl Halczenko,
Marie A. Holahan,
Robert J. Lynch,
Gary R. Sitko,
Maria T. Stranieri, and
George D. Hartman
[Full Article -
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4592-4601
| N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP Potassium Channel Openers. Modifications on the Western Region
Cyrus J. Ohnmacht,
Keith Russell,
James R. Empfield,
Cathy A. Frank,
Keith H. Gibson,
Daniel R. Mayhugh,
Frances M. McLaren,
Howard S. Shapiro,
Frederick J. Brown,
Diane A. Trainor,
Christopher Ceccarelli,
Margaret M. Lin,
Brian B. Masek,
Janet M. Forst,
Robert J. Harris,
James M. Hulsizer,
Joseph J. Lewis,
Stuart M. Silverman,
Reed W. Smith,
Paul J. Warwick,
Sen T. Kau,
Alexa L. Chun,
Thomas L. Grant,
Burton B. Howe,
Jack H. Li,
Shephali Trivedi,
Tracy J. Halterman,
Christopher Yochim,
Martin C. Dyroff,
M. Kirkland, and
Kathleen L. Neilson
[Full Article -
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4602-4607
| Synthesis and Biological Profile of the Enantiomers of [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]furan- 2-ylmethanone (Cyclazosin), a Potent Competitive  1B-Adrenoceptor Antagonist
Dario Giardinà,
Mauro Crucianelli,
Roberta Romanelli,
Amedeo Leonardi,
Elena Poggesi, and
Carlo Melchiorre
[Full Article -
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4608-4621
| Synthesis, Structure-Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy- N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and Related Compounds
Elizabeth A. Kuo,
Philip T. Hambleton,
David P. Kay,
Phillip L. Evans,
Saroop S. Matharu,
Edward Little,
Neil McDowall,
C. Beth Jones,
Charles J. R. Hedgecock,
Christopher M. Yea,
A. W. Edith Chan,
Peter W. Hairsine,
Ian R. Ager,
W. Roger Tully,
Richard A. Williamson, and
Robert Westwood
[Full Article -
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4622-4629
| Molecular Electronic Properties of a Series of 4-Quinolinecarbinolamines Define Antimalarial Activity Profile
Apurba K. Bhattacharjee and
Jean M. Karle
[Full Article -
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4630-4642
| Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors
Suvit Thaisrivongs,
Donna L. Romero,
Ruben A. Tommasi,
Musiri N. Janakiraman,
Joseph W. Strohbach,
Steve R. Turner,
Carolyn Biles,
Raymond R. Morge,
Paul D. Johnson,
Paul A. Aristoff,
Paul K. Tomich,
Janet C. Lynn,
Miao-Miao Horng,
Kong-Teck Chong,
Roger R. Hinshaw,
W. Jeffrey Howe,
Barry C. Finzel, and
Keith D. Watenpaugh
[Full Article -
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4643-4653
| Analogs of 3-Hydroxy-1H-1-benzazepine-2,5-dione: Structure-Activity Relationship at N-Methyl-D-aspartate Receptor Glycine Sites
Anthony P. Guzikowski,
Sui Xiong Cai,
Stephen A. Espitia,
Jon E. Hawkinson,
James E. Huettner,
Daniel F. Nogales,
Minhtam Tran,
Richard M. Woodward,
Eckard Weber, and
John F. W. Keana
[Full Article -
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4654-4666
| High-Affinity -Aminobutyric Acid A/Benzodiazepine Ligands: Synthesis and Structure-Activity Relationship Studies of a New Series of Tetracyclic Imidazoquinoxalines
John W. Mickelson,
E. Jon Jacobsen,
Donald B. Carter,
Haesook K. Im,
Wha Bin Im,
Peggy J. K. D. Schreur,
Vimala H. Sethy,
Andy H. Tang,
James E. McGee, and
James D. Petke
[Full Article -
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4667-4675
| 6-Phenyl-1,4-dihydropyridine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists
Ji-long Jiang,
A. Michiel van Rhee,
Neli Melman,
Xiao-duo Ji, and
Kenneth A. Jacobson
[Full Article -
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4676-4681
| In Vitro and in Vivo Evaluation of 6-Azido-2',3'-dideoxy-2'-fluoro--D-arabinofuranosylpurine and N6-Methyl-2',3'-dideoxy-2'-fluoro--D-arabinofuranosyladenine as Prodrugs of the Anti-HIV Nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI
Tanya Koudriakova,
Konstantine K. Manouilov,
Kirupa Shanmuganathan,
Lakshmi P. Kotra,
F. Douglas Boudinot,
Erica Cretton-Scott,
Jean-Pierre Sommadossi,
Raymond F. Schinazi, and
Chung K. Chu
[Full Article -
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4682-4686
| Structure-Activity Relationships of 4-Hydroxy-3-nitroquinolin-2(1H)-ones as Novel Antagonists at the Glycine Site of N-Methyl-D-aspartate Receptors
Sui Xiong Cai,
Zhang-Lin Zhou,
Jin-Cheng Huang,
Edward R. Whittemore,
Zizi O. Egbuwoku,
Jon E. Hawkinson,
Richard M. Woodward,
Eckard Weber, and
John F. W. Keana
[Full Article -
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4687-4687
| Biotechnology Intelligence Unit. Structure-Property Correlations in Drug Development Edited by Han van de Waterbeemd. Academic Press, Inc., San Diego, CA. Academic Press Ltd., London, United Kingdom. R. G. Landes Co., Georgetown, TX. 1996. 210 pp. 18.5 × 26 cm. ISBN 0-12-711650-8. $69.95.
Donald T. Witiak
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4687-4687
| The Practice of Medicinal Chemistry Edited by Camille G. Wermuth. Academic Press, London. 1996. xvii + 968 pp. 17 × 25 cm. ISBN 0-12-744640-0. $89.00.
Manfred E. Wolff
[Full Article -
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4687-4688
| Bioorganic Chemistry. A Chemical Approach to Enzyme Action. Third Edition Hermann Dugas. Springer-Verlag, New York. 1996. xvii + 700 pp. 16 × 24 cm. ISBN 0-387-94494-X. $49.95.
Joseph G. Cannon
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4688-4688
| Books of Interest
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